From Bench to Bedside

نویسندگان

  • Iftikhar J. Kullo
  • Robert D. Simari
  • Robert S. Schwartz
چکیده

Since the initial experiments nearly a decade ago, remarkable progress has been made in the field of vascular gene transfer, and trials with human subjects already are under way. The potential of vascular wall gene transfer as therapy for various vascular diseases is considerable.1,2 The purpose of this review is 2-fold: (1) to delineate the methods and principles underlying vascular gene transfer and (2) to discuss how gene transfer might be used in the treatment of vascular diseases.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside

Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...

متن کامل

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

متن کامل

Highlights of Keystone symposium ‘Fibrosis: from bench to bedside’

This report is based on the ‘Fibrosis: from bench to bedside’ symposium from the Keystone Symposia meeting series, Keystone, Colorado, 23 to 28 March 2014. It was a fascinating symposium with high quality talks, workshops, and well attended poster sessions.

متن کامل

Bedside–to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria

Congestive heart failure (CHF) is a chronic condition usually without cure. Significant developments, particularly those addressing pathophysiology, mainly started at the bench. This approach has seen many clinical observations initially explored at the bench, subsequently being trialed at the bedside, and eventually translated into clinical practice. This evidence, however, has several limitat...

متن کامل

Allergy and asthma: from the bedside to the bench and international actions.

The interdependence of the bench to the bedside has been demonstrated for many years. The example in allergy and asthma has been used to show how clinical observations can be dissected by epidemiologic and basic scientific studies leading to a better concept of rhinitis, asthma and their comorbidities. From research, public health programs can be designed.

متن کامل

Metabolic syndrome and cancer: from bedside to bench and back.

As older patients present with an average of three comorbidities beside their cancer, geriatric oncology can provide unique clues to translational research in aging and cancer. We illustrate this approach with the example of the metabolic syndrome and cancer. Epidemiologic and clinical cohorts highlighted an association between the metabolic syndrome and a higher risk and worse prognosis of var...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1999